Special “Cancers” issue: Targeting STAT3 and STAT5 in cancer

The Special Issue “Targeting STAT3 and STAT5 in Cancer”, edited by Prof. Dr. Richard Moriggl, Prof. Dr. Patrick Gunning and Prof. Dr. György Miklós Keserü was published with 26 papers in Cancers (peer-reviewed Open Access journal of oncology published monthly online by MDPI). Read the full text of the papers at the following link:

Special Issue “Targeting STAT3 and STAT5 in Cancer”

Paper published in Molecular Metabolism

Our group successfully published a paper on STAT5 signaling in lipid metabolism in the journal “Molecular Metabolism”.

Doris Kaltenecker and Katrin Spirk were working together on this project and investigated the function of STAT5 in brown adipose tissue thermogenesis, as well as its role in the brown remodelling of white adipose tissue. They demonstrate in their work the importance of STAT5 for the functionality and the β-adrenergic responsiveness of thermogenic adipose tissue.

STAT5 is required for lipid breakdown and beta-adrenergic responsiveness of brown adipose tissue.
Kaltenecker D, Spirk K, Ruge F, Grebien F, Herling M, Rupprecht A, Kenner L, Pohl EE, Mueller KM, Moriggl R. Mol Metab. 2020 May 27:101026. doi: 10.1016/j.molmet. 2020. 101026. Online ahead of print. PMID: 32473405

Congratulations Doris and Katrin!

Collaborative paper published in Cancers

Collaborative efforts with the Medical University of Vienna resulted in a new manuscript concerning STAT5 activation in CD34+/CD38 MPN stem cells, published in the journal Cancers. The article is a part of the special issue Targeting STAT3 and STAT5 in Cancer.

STAT5 is Expressed in CD34+/CD38 Stem Cells and Serves as a Potential Molecular Target in Ph-Negative Myeloproliferative Neoplasms.
Hadzijusufovic E, Keller A, Berger D, Greiner G, Wingelhofer B, Witzeneder N, Ivanov D, Pecnard E, Nivarthi H, Schur FKM, Filik Y, Kornauth C, Neubauer HA, Müllauer L, Tin G, Park J, de Araujo ED, Gunning PT, Hoermann G, Gouilleux F, Kralovics R, Moriggl R, Valent P.
Cancers (Basel). 2020 Apr 21;12(4). pii: E1021. doi: 10.3390/cancers12041021.

Congratulations to all authors involved!

Collaborative paper published in The Journal of Clinical Investigation

Due to our collaboration with the brilliant researchers at the Technical University of Denmark, we gained novel insights into the role of STAT5 in the programming of innate gamma delta T cells in the neonatal microenvironment. Together, we have now published this study in The Journal of Clinical Investigation. These findings could benefit and contribute to future therapies for human immunological diseases.

The neonatal microenvironment programs innate γδ T cells through the transcription factor STAT5.
Kadekar D, Agerholm R, Rizk J, Neubauer HA, Suske T, Maurer B, Viñals MT, Comelli EM, Taibi A, Moriggl R, Bekiaris V.
J Clin Invest. 2020 Apr 13. pii: 131241. doi: 10.1172/JCI131241. 

Graphical Abstract

Read more about our new insights into immune cell biology relevant for treating human disease at our University press-release page.

We congratulate all involved authors!

Heidi Neubauer is selected for the “VetWoman” Program

We are proud to announce that Dr. Heidi Neubauer was chosen to be 1 out of 10 participants in the “VetWoman” Female Career Development Program 2020. In this initiative, founded this year by the Vetmed University, talented early-career female researchers are trained and coached in leadership and management skills for a duration of 18-months.

Heidi presenting her research at the VetWoman kick-off meeting. Copyright: Wijnants Alexander/Vetmeduni Vienna 

Heidi and the other 9 selected candidates were each assigned their own individual coach to support them through the 18-month program. Additionally, training seminars, events, workshops and networking will be part of the initiative.

VetWoman 2020 group picture from the Kick-Off event on February 19th, showing the 10 selected participants and assigned individual coaches.
Copyright: Suchanek Thomas

Read more about the program here.

Congratulations Heidi! 🙂

Richard Moriggl and Heidi Neubauer receive Awards at the Vetmed Science Day 2019

Gain more insight into the Vetmeduni Science day in this video, created by the Vetmeduni Vienna.

At this year’s Vetmeduni Science Day, there were interesting talks, poster sessions from students, networking opportunities as well as awards given in recognition of outstanding scientific contributions from the previous year. Members of the Moriggl lab, Richard Moriggl and Heidi Neubauer, were very successful and received three awards.

Receiving this year’s well deserved awards at the 2019 Vetmeduni Science Day event. Picture credits: T. Suchanek/Vetmeduni Vienna.

Lab head Richard Moriggl was awarded with the ‘Vetmeduni Vienna ‘Scientist of the Year’ Award, non-clinical category: Highest number of citations’. 

Heidi Neubauer was awarded with the ‘Vetmeduni Vienna ‘Young Scientist of the Year’ Award, non-clinical category: Highest number of citations’ and the ‘Vetmeduni Vienna ‘Young Scientist of the Year’ Award, non-clinical category: Most third-party funding’.

Richard and Heidi on stage while receiving their awards.

Read more on the Vetmeduni Science Day 2019.

7th Annual Meeting of the International Cytokine & Interferon Society

From the 20th – 23rd October members of the Moriggl lab were excited to join the 7th Annual Meeting of the International Cytokine & Interferon Society that took place in the beautiful Hofburg in Vienna.

Heidi presenting her research on the beautiful stage

Our group was represented by well-received posters from Tobias Suske, Anna Orlova, Christina Maria Wagner and Helena Sorger. A highlight of the conference was an interesting selected short talk by Heidi Neubauer about the gain-of-function STAT5B N642H mutation as a driver of mature T cell leukemia/ lymphoma.