Unit for Functional Cancer Genomics
The Special Issue “Targeting STAT3 and STAT5 in Cancer”, edited by Prof. Dr. Richard Moriggl, Prof. Dr. Patrick Gunning and Prof. Dr. György Miklós Keserü was published with 26 papers in Cancers (peer-reviewed Open Access journal of oncology published monthly online by MDPI). Read the full text of the papers at the following link:
Special Issue “Targeting STAT3 and STAT5 in Cancer”
We, the Orlova Group Inhibitor Team, have used the Covid-19 times productively. Testing new compounds for STAT5 inhibition, we have done over 300 cytotox assays together in shift work.
Our group successfully published a paper on STAT5 signaling in lipid metabolism in the journal “Molecular Metabolism”.
Doris Kaltenecker and Katrin Spirk were working together on this project and investigated the function of STAT5 in brown adipose tissue thermogenesis, as well as its role in the brown remodelling of white adipose tissue. They demonstrate in their work the importance of STAT5 for the functionality and the β-adrenergic responsiveness of thermogenic adipose tissue.
STAT5 is required for lipid breakdown and beta-adrenergic responsiveness of brown adipose tissue.
Kaltenecker D, Spirk K, Ruge F, Grebien F, Herling M, Rupprecht A, Kenner L, Pohl EE, Mueller KM, Moriggl R. Mol Metab. 2020 May 27:101026. doi: 10.1016/j.molmet. 2020. 101026. Online ahead of print. PMID: 32473405
Congratulations Doris and Katrin!
Collaborative efforts with the Medical University of Vienna resulted in a new manuscript concerning STAT5 activation in CD34+/CD38− MPN stem cells, published in the journal Cancers. The article is a part of the special issue Targeting STAT3 and STAT5 in Cancer.
STAT5 is Expressed in CD34+/CD38– Stem Cells and Serves as a Potential Molecular Target in Ph-Negative Myeloproliferative Neoplasms.
Hadzijusufovic E, Keller A, Berger D, Greiner G, Wingelhofer B, Witzeneder N, Ivanov D, Pecnard E, Nivarthi H, Schur FKM, Filik Y, Kornauth C, Neubauer HA, Müllauer L, Tin G, Park J, de Araujo ED, Gunning PT, Hoermann G, Gouilleux F, Kralovics R, Moriggl R, Valent P.
Cancers (Basel). 2020 Apr 21;12(4). pii: E1021. doi: 10.3390/cancers12041021.
Congratulations to all authors involved!
Due to our collaboration with the brilliant researchers at the Technical University of Denmark, we gained novel insights into the role of STAT5 in the programming of innate gamma delta T cells in the neonatal microenvironment. Together, we have now published this study in The Journal of Clinical Investigation. These findings could benefit and contribute to future therapies for human immunological diseases.
The neonatal microenvironment programs innate γδ T cells through the transcription factor STAT5.
Kadekar D, Agerholm R, Rizk J, Neubauer HA, Suske T, Maurer B, Viñals MT, Comelli EM, Taibi A, Moriggl R, Bekiaris V.
J Clin Invest. 2020 Apr 13. pii: 131241. doi: 10.1172/JCI131241.
Read more about our new insights into immune cell biology relevant for treating human disease at our University press-release page.
We congratulate all involved authors!
We are proud to announce that Dr. Heidi Neubauer was chosen to be 1 out of 10 participants in the “VetWoman” Female Career Development Program 2020. In this initiative, founded this year by the Vetmed University, talented early-career female researchers are trained and coached in leadership and management skills for a duration of 18-months.
Heidi and the other 9 selected candidates were each assigned their own individual coach to support them through the 18-month program. Additionally, training seminars, events, workshops and networking will be part of the initiative.
Read more about the program here.
Congratulations Heidi! 🙂
To say farewell to one of our amazing Master students (Katrin Sommer), some of us spent a wonderful day skiing at Hochkar. Just like her Master thesis defense, Katrin rocked her first skiing lesson here in Austria. We will miss you as a part of the lab, Katrin!
At this year’s Vetmeduni Science Day, there were interesting talks, poster sessions from students, networking opportunities as well as awards given in recognition of outstanding scientific contributions from the previous year. Members of the Moriggl lab, Richard Moriggl and Heidi Neubauer, were very successful and received three awards.
Lab head Richard Moriggl was awarded with the ‘Vetmeduni Vienna ‘Scientist of the Year’ Award, non-clinical category: Highest number of citations’.
Heidi Neubauer was awarded with the ‘Vetmeduni Vienna ‘Young Scientist of the Year’ Award, non-clinical category: Highest number of citations’ and the ‘Vetmeduni Vienna ‘Young Scientist of the Year’ Award, non-clinical category: Most third-party funding’.
Read more on the Vetmeduni Science Day 2019.
From the 20th – 23rd October members of the Moriggl lab were excited to join the 7th Annual Meeting of the International Cytokine & Interferon Society that took place in the beautiful Hofburg in Vienna.
Our group was represented by well-received posters from Tobias Suske, Anna Orlova, Christina Maria Wagner and Helena Sorger. A highlight of the conference was an interesting selected short talk by Heidi Neubauer about the gain-of-function STAT5B N642H mutation as a driver of mature T cell leukemia/ lymphoma.
To show our great team-working spirits, 3 members of the Moriggl lab (+ Lindsay Kosack from the CeMM) completed a scenic relay marathon in the Wachau. Thanks Anna for organizing!
