Unit for Functional Cancer Genomics
The Special Issue “Targeting STAT3 and STAT5 in Cancer”, edited by Prof. Dr. Richard Moriggl, Prof. Dr. Patrick Gunning and Prof. Dr. György Miklós Keserü was published with 26 papers in Cancers (peer-reviewed Open Access journal of oncology published monthly online by MDPI). Read the full text of the papers at the following link:
Special Issue “Targeting STAT3 and STAT5 in Cancer”
Our group successfully published a paper on STAT5 signaling in lipid metabolism in the journal “Molecular Metabolism”.
Doris Kaltenecker and Katrin Spirk were working together on this project and investigated the function of STAT5 in brown adipose tissue thermogenesis, as well as its role in the brown remodelling of white adipose tissue. They demonstrate in their work the importance of STAT5 for the functionality and the β-adrenergic responsiveness of thermogenic adipose tissue.
STAT5 is required for lipid breakdown and beta-adrenergic responsiveness of brown adipose tissue.
Kaltenecker D, Spirk K, Ruge F, Grebien F, Herling M, Rupprecht A, Kenner L, Pohl EE, Mueller KM, Moriggl R. Mol Metab. 2020 May 27:101026. doi: 10.1016/j.molmet. 2020. 101026. Online ahead of print. PMID: 32473405
Congratulations Doris and Katrin!
Collaborative efforts with the Medical University of Vienna resulted in a new manuscript concerning STAT5 activation in CD34+/CD38− MPN stem cells, published in the journal Cancers. The article is a part of the special issue Targeting STAT3 and STAT5 in Cancer.
STAT5 is Expressed in CD34+/CD38– Stem Cells and Serves as a Potential Molecular Target in Ph-Negative Myeloproliferative Neoplasms.
Hadzijusufovic E, Keller A, Berger D, Greiner G, Wingelhofer B, Witzeneder N, Ivanov D, Pecnard E, Nivarthi H, Schur FKM, Filik Y, Kornauth C, Neubauer HA, Müllauer L, Tin G, Park J, de Araujo ED, Gunning PT, Hoermann G, Gouilleux F, Kralovics R, Moriggl R, Valent P.
Cancers (Basel). 2020 Apr 21;12(4). pii: E1021. doi: 10.3390/cancers12041021.
Congratulations to all authors involved!
Due to our collaboration with the brilliant researchers at the Technical University of Denmark, we gained novel insights into the role of STAT5 in the programming of innate gamma delta T cells in the neonatal microenvironment. Together, we have now published this study in The Journal of Clinical Investigation. These findings could benefit and contribute to future therapies for human immunological diseases.
The neonatal microenvironment programs innate γδ T cells through the transcription factor STAT5.
Kadekar D, Agerholm R, Rizk J, Neubauer HA, Suske T, Maurer B, Viñals MT, Comelli EM, Taibi A, Moriggl R, Bekiaris V.
J Clin Invest. 2020 Apr 13. pii: 131241. doi: 10.1172/JCI131241.
Read more about our new insights into immune cell biology relevant for treating human disease at our University press-release page.
We congratulate all involved authors!
